Emergence of a r-type ca2+ channel (cav 2.3) contributes to cerebral artery...
The invention relates to methods and products for treatment of a neurological defect such as a subarachnoid hemorrhage or cerebral vasospasm. Specifically, R-type voltage-gated calcium channel...
View ArticleLactam acetamides as calcium channel blockers
wherein Ar1, n, R1, X and Y are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating conditions and disorders using...
View ArticleNovel substituted octahydrocyclopenta[c]pyrrol-4-amines as calcium channel...
wherein L1, L2, R1, R2, and R3 are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating conditions and disorders...
View ArticleSubstituted octahydrocyclopenta[c]pyrroles as calcium channel modulators
wherein a, R1, R2, R3, and R4 are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating conditions and disorders...
View ArticleCompositions for potentiating apoposis signals in tumour cells
The present invention concerns a composition for potentiating formation of DISC (Death Inducing Signaling Complex) macro-complex and for inducing apoptotic signal mediated by death receptors in tumour...
View ArticleNovel benzenesulfonamides as calcium channel blockers
wherein L1, R1, R2, R3, R4, R5, R6, R7 and Rc are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating conditions...
View ArticleInterlaced method for treating cancer or a precancerous condition
The present invention provides a method for treating a disease or condition in a mammal which comprises the steps of; administering a therapeutically effective amount of a T type calcium channel...
View ArticleT type calcium channel blockers and the treatment of diseases
The present invention provides a method for treating a disease or condition in a mammal associated with influx of extracellular calcium via T type calcium channels, which comprises administering to...
View ArticleSubstituted octahydropyrrolo[1,2-a]pyrazines as calcium channel blockers
and salts thereof, wherein Z1, Z2, Z3, Z4, R1, R2, and R3 are as defined in the specification; (b) compositions comprising such compounds and salts; and (c) methods of use of such compounds, salts,...
View ArticleNovel benzenesulfonamides as calcium channel blockers
wherein L1, R1, R2, R3, R4, R5, R6, R7 and Rc are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating conditions...
View ArticleNovel 6-pyrazolylamido-3-substituted azabicyclo[3.1.0]hexane compounds as...
The present invention relates to a 6-pyrazolylamido-3-substituted azabicyclo[3.1.0]hexane derivatives useful as calcium channel blockers, pharmaceutically acceptable salts thereof and medical use of...
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